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Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium. What should my health care professional know before I take Esomeprazole? Nexium capsules should be applied one hour before a meal. You will need to choose between taking Nexium or breastfeeding your baby. Esomeprazole works best if taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. For gastroesophageal reflux disease. Nexium is used to treat the infection, which is responsible for the majority of gastric ulcers. By blocking the enzyme in the wall of the stomach that produces acid. For gastroesophageal reflux disease, Esomeprazole has demonstrated pharmacological and clinical benefits beyond those seen with the other proton pump inhibitors.