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Valaciclovir is an antiviral drug used in the management of herpes simplex and herpes zoster As you learn more about genital herpes, and also about Valtrex, the only once-daily medicine that can help reduce the number of outbreaks you have. Valtrex is most effective if it is started within 48 hours of when the rash first appears. Valaciclovir is a drug, an esterified version of aciclovir that has greater oral bioavailability than aciclovir. Valaciclovir is most effective if it is started within 48 hours of when the rash first appears. Genital herpes not only recurs, it can be passed on to sexual partners.
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