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Because estrogens have been linked with an increased risk of uterine and endometrial cancer, it is essential to have regular checkups and to report any unusual vaginal bleeding to your doctor immediately. Long-term treatment with conjugated estrogens may increase your risk of stroke or blood clots. Long-term treatment with conjugated estrogens may increase your risk of developing these conditions. There are no restrictions on food, beverages, or activity while taking conjugated estrogens, tell your doctor if you are pregnant. Women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Before taking conjugated estrogens, tell your doctor if you are pregnant. Conjugated estrogens are sometimes taken on a daily basis.