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Prednisone is less likely than other corticosteroids to be secreted in breast milk, but it should be ensured that if antibiotics are required, that they are given in effective doses. Corticosteroids, including prednisone, are commonly used to suppress the immune system. A dose lasts about a day or a day and a half. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone most often is used for treating allergies, arthritis, breathing problems, certain blood disorders, certain eye diseases, cancer or psoriasis. Deltasone is used in much higher doses than the levels of corticosteroids produced naturally by the body. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired.